Vladimir Uversky,Yuri Lyubchenko's Bio-nanoimaging: Protein Misfolding and Aggregation PDF

By Vladimir Uversky,Yuri Lyubchenko

ISBN-10: 0123944317

ISBN-13: 9780123944313

Bio-Nanoimaging: Protein Misfolding & Aggregation offers a distinct creation to either novel and verified nanoimaging strategies for visualisation and characterization of misfolded and aggregated protein species. The publication is split into 3 sections overlaying: - Nanotechnology and nanoimaging expertise, together with cryoelectron microscopy of beta(2)-microglobulin, learning amyloidogensis by means of be anxious; and scanning tunneling microscopy of protein deposits - Polymorphisms of protein misfolded and aggregated species, together with fibrillar polymorphism, amyloid-like protofibrils, and insulin oligomers - Polymorphisms of misfolding and aggregation techniques, together with a number of pathways of lysozyme aggregation, misfolded intermediate of a PDZ area, and micelle formation by means of human islet amyloid polypeptide

Protein misfolding and aggregation is a fast-growing frontier in molecular medication and protein chemistry. comparable issues comprise cataracts, arthritis, cystic fibrosis, late-onset diabetes mellitus, and diverse neurodegenerative illnesses like Alzheimer's and Parkinson's. Nanoimaging expertise has proved an important in realizing protein-misfolding pathologies and in strength drug layout aimed toward the inhibition or reversal of protein aggregation. utilizing those applied sciences, researchers can visual display unit the aggregation procedure, visualize protein aggregates and examine their properties.

  • Provides useful examples of nanoimaging study from best molecular biology, telephone biology, protein chemistry, biotechnology, genetics, and pharmaceutical labs
  • Includes over 2 hundred colour photographs to demonstrate the ability of varied nanoimaging applied sciences
  • Focuses on nanoimaging innovations utilized to protein misfolding and aggregation in molecular medicine

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Bio-nanoimaging: Protein Misfolding and Aggregation by Vladimir Uversky,Yuri Lyubchenko

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